|ABSTRACT This study was designed to determine the effects of peer education on awareness and attitude towards HIV and AIDs among in- school adolescents in Enugu State. To guide this study, six research questions were posed and six null hypotheses formulated and tested at 0.05 level of significance. The research design used in this study was non-equivalent control group Quasi-Experimental involving experimental treatment group and a control group. The sample for the study was made up of 231 students in SSII. A random sampling technique was used to draw two co-educational schools from each of the local government areas and they were randomly assigned to both experimental and control groups. Three trained research assistants were used for the experiment while the control group was not exposed to any treatment. A 20-item researcher designed questionnaire titled HIV and AIDS Awareness and Attitude Questionnaire (HAAAQ) was used for the study. The reliability of the instrument was determined using Cronbach Alpha statistic which yielded Alpha co-efficient values of 0.80 and 0.79 for the two clusters. Measures were taken to control the extraneous variables. A pretest of the questionnaire was administered before the treatment on peer education that lasted for six weeks. The data collected were analysed using Mean, and Analysis of Covariance.(ANCOVA) The Results revealed that: students exposed to treatment on peer education have higher awareness of HIV and AIDS when compared to those of the control group; gender is not a significant factor influencing students awareness towards HIV and AIDS, students exposed to treatment on peer education have a higher positive attitude towards HIV and AIDS compared to those of the control. Furthermore, gender does not significantly influence students’ attitude towards HIV and AIDS. Also, there is no interaction effect of gender and peer education on students’ awareness as well as attitude towards HIV and AIDS. It was recommended among others that school authorities should integrate play method in the teaching of sexuality issues as this will create room for students to utilize peer approach in learning; while federal and state ministries of Education should organize and sponsor workshops and seminars for school guidance counselors on how to implement peer education on awareness and attitude towards HIV and AIDS among in-school adolescents.