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The Effect of Temperature Fluctuation In The Tropics On The Viscoelastic Properties of Clotrimazole (an antifungal) Cream Bases
Abstract:
The physicochemical factors affecting semi-solids and in particular emulsified creams have been reviewed. Temperature, humidity, pH changes, Oxidation-rednction processes and microbial contamination are such factors that generally affect the stability of Pharmaceutical and Cosmetic creams. The flow properties and types of flow of various types of pharmaceutical fluids and semi-solids have also been outlined. An investigation on the macroscopical and rheological properties such as apparent plastic viscosity, yield stress and thixotropy using Ferrenti-Shirley cone and plate viscometry was carried out on various cream bases at different temperatures. Cetostearyl alcohol/Cetyltrimethyl Ommonium oromide were used as mixed emulsifier. The effects of alcohol/surfactant ratio and the total mixed emulsifier concentrations on the viscoelastic properties have also been investigated, The results of these investigations indicated that temperature fluctuations common to tropical climates affect the physical stability of the creams drastically. It was found that the consistency usually increases with rise in temperature to a maximum of around 20° – 27° and decreases with further increase therefrom. An exact temperature of maximum stability of 20° was also found to be the same for the commercial sample “Canesten Cream” in the comparative studies conducted in this work,
The Effect of Temperature Fluctuation In The Tropics On The Viscoelastic Properties of Clotrimazole (an antifungal) Cream Bases
