AMELIORATIVE EFFECTS OF L-GLUTAMINE ON RECTAL TEMPERATURE, HAEMATOLOGICAL AND OXIDATIVE STRESS CHANGES IN RED SOKOTO GOATS DURING THE HOT-DRY SEASON

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AMELIORATIVE EFFECTS OF L-GLUTAMINE ON RECTAL TEMPERATURE, HAEMATOLOGICAL AND OXIDATIVE STRESS CHANGES IN RED SOKOTO GOATS DURING THE HOT-DRY SEASON

Abstract:

The experiment was conducted with the aim of determining the ameliorative effects of L-glutamine administration on rectal temperature, haematological and oxidative stress changes in Red Sokoto goats during the hot-dry season. Twenty eight apparently healthy adult Red Sokoto goats of about 1-year-old, comprising 14 bucks (7 experimental and 7 control) and 14 non-pregnant does (7 experimental and 7 control) served as subject of the study. Goats in the experimental group were administered Lglutamine at 0.2 g/kg body weight per os once daily, while those in the control group were given distilled water for 21 days. Rectal temperature and, blood samples for haematological and biochemical analyses, were obtained 3 days before, during and on day 7 after L-glutamine administration. The thermal environmental variables of drybulb temperature, relative humidity, and temperature-humidity index during the study period had range values of 24.5 – 35.2 °C, 41.7 – 84.0 % and 74.1 – 84.0, respectively. The mean rectal temperature of 38.78 ± 0.06 °C recorded in experimental group was lower than the corresponding value of 38.93 ± 0.06 °C recorded in control group, during the period L-glutamine administration. The packed cell volume, haemoglobin concentration, erythrocyte count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, and total leucocyte, neutrophil and lymphocyte counts, and neutrophil:lymphocyte ratio were higher (P < 0.05) in experimental group as compared to the control group. Erythrocyte osmotic fragility in experimental group was lower (P < 0.05) than in the control group only at 0.5 and 0.7 % during the period of L-glutamine administration. The MDA concentration in the experimental group (1.47 ± 0.1 nmol/L) was lower (P < 0.05) than the corresponding value of 1.75 ± 0.1 nmol/L recorded in the control group, during Lglutamine administration. In the experimental group, SOD activity (2.29 ± 0.04 IU/L) was higher (P < 0.05) than that obtained in the control group (2.10 ± 0.04 IU/L) during L-glutamine administration. The glutathione peroxidase activities was higher (P < 0.05) in experimental than the control goats during L-glutamine administration. Catalase activity recorded in the experimental goats (48.96 ± 0.9 IU/L) was significantly (P < 0.05) higher than that obtained in control goats (44.04 ± 0.9 IU/L) during the period of L-glutamine administration. In conclusion, L-glutamine ameliorated the heat stressinduced changes in rectal temperature, haematological and oxidative stress parameters of Red Sokoto goats during the hot-dry season.

AMELIORATIVE EFFECTS OF L-GLUTAMINE ON RECTAL TEMPERATURE, HAEMATOLOGICAL AND OXIDATIVE STRESS CHANGES IN RED SOKOTO GOATS DURING THE HOT-DRY SEASON

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