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ACCURACY OF THE SPOT URINARY MICROALBUMINURIA: CREATININE RATIO COMPARED TO 24 – HOUR URINE PROTEIN IN DETECTING PROTEINURIA IN PREECLAMPSIA
Abstract
Objective: The purpose of this study is to determine if a patient’s protein values using the spot urinary microalbuminuria/creatinine ratio correlates with the 24- hour value to confirm the diagnosis of preeclampsia. Study Design: The study population included 80 patients with hypertensive disorders of pregnancy. Patients’ urine were collected over 24 hours. The urine volume, and total protein in the 24-hour samples were evaluated. Urine dipstick test and the microalbuminuria /creatinine ratio in a spot urine sample were compared to the 24-hour results. The test of validity and reliability were done using the sensitivity, specificity, false positive and the false negative rate. Also assessed were the positive and negative predictive value and the accuracy. Results: Eighty pregnant patients completed the study.The visual dipstick has a sensitivity of 72.1%,specificity of 68.4%, positive predictive value(PPV) of 88%,negative predictive value(NPV) of 43.3%,false positive rate(FPR) of 31.6%,false negative rate(FNR) of 27.9%, and accuracy of 71.3%. The urinary microalbumin dipsticks had sensitivity of 98.4%,specificity of 36.4%,PPV of 83.3%,NPV of 87.5%,FPR of 63.2%,FNR of 1.6%,and accuracy of 83.8%.The urinary microalbumin:creatinine ratio has sensitivity of 95.1%, specificity of 89.5%,PPV of 96.7%,NPV of 85%,FPR of 10.5%,FNR of 4.9%,and accuracy of 93.8%.The result showed a strong correlation between the random urinary microalbumin-to-creatinine ratio and the quantitation of 24-hour proteinuria. Conclusion: The presented data support a strong correlation between random urinary microalbimin-to-creatinine ratio and quantitation of 24hour proteinuria in hospitalized pregnant patients with preeclampsia.
