CLINICAL SIGNIFICANCE OF ELEVATED LEVELS OF THE CARDIAC BIOMARKER-TROPONIN T OBSERVED IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT LAGOS UNIVERSITY TEACHING HOSPITAL, LAGOS

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CLINICAL SIGNIFICANCE OF ELEVATED LEVELS OF THE CARDIAC BIOMARKER-TROPONIN T OBSERVED IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT LAGOS UNIVERSITY TEACHING HOSPITAL, LAGOS

Abstract

Background: Observational study of predialysis patients with chronic kidney disease (CKD)
attending nephrology clinic at Lagos University Teaching Hospital to determine clinical
significance of elevated levels of cardiac troponins T (CTT) and possible associated factors.
Method: One hundred and forty three (143) patients with CKD and no prior history of
myocardial infarction were recruited and their serum levels of CTT were determined within 3
months of sample collection and storage at -80° C. ECG findings and clinical variables were
compared. The 99th percentile cut-off value was derived using healthy individuals that met the
inclusion criteria.
Results: Mean blood CTT level was significantly higher in CKD patients compared to the
general population. The 99th percentile value derived in the reference sample population was
48.02pg/ml. Statistical analysis showed significant association of CTT elevation with left
ventricular hypertrophy, decreased renal function and age.
Conclusion: CTT is generally elevated in pre-dialysis patients with CKD and a single elevated
blood level of CTT above the 99th percentile suggest ACS that has not been noticed. Serial
rising levels of CTT and other clinical features are of diagnostic significance in diagnosis and
management of these patients with acute coronary syndrome in asymptomatic situations.

CLINICAL SIGNIFICANCE OF ELEVATED LEVELS OF THE CARDIAC BIOMARKER-TROPONIN T OBSERVED IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT LAGOS UNIVERSITY TEACHING HOSPITAL, LAGOS

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