THEORETICAL AND COMPUTATIONAL MODELING OF AN IMPLANTABLE BIOMEDICAL DEVICE FOR LOCALIZED HYPERTHERMIA AND DRUG DELIVERY

THEORETICAL AND COMPUTATIONAL MODELING OF AN IMPLANTABLE BIOMEDICAL DEVICE FOR LOCALIZED HYPERTHERMIA AND DRUG DELIVERY

Abstract:

Localized hyperthermia and targeted drug delivery are promising therapeutic approaches in the field of biomedical engineering for the treatment of various diseases, including cancer. In this study, we present a theoretical and computational modeling framework for an implantable biomedical device capable of achieving localized hyperthermia and controlled drug delivery.

The proposed device consists of an implantable unit equipped with miniature heating elements and drug reservoirs. The theoretical modeling involves the development of mathematical models to describe the heat generation and transfer within the device, as well as the drug release kinetics from the reservoirs. By considering the relevant physical and chemical processes, such as heat conduction, convection, and drug diffusion, we establish a comprehensive understanding of the device’s behavior.

To complement the theoretical framework, computational simulations are performed to validate the model’s predictions and explore the device’s performance under various operating conditions. Finite element analysis (FEA) is employed to simulate the heat distribution within the target tissue, ensuring precise control over the localized hyperthermia. Additionally, computational fluid dynamics (CFD) simulations are employed to assess the drug release profile and optimize the drug delivery process.

Through the integration of theoretical models and computational simulations, our study provides insights into the optimal design parameters for the implantable biomedical device. These insights enable the customization of the device to suit specific patient requirements and disease characteristics, maximizing therapeutic efficacy while minimizing potential side effects.

The proposed implantable biomedical device holds promise for localized hyperthermia and drug delivery, offering a targeted and minimally invasive approach to disease treatment. The theoretical and computational modeling framework presented in this study serves as a valuable tool for device optimization, facilitating the development of safe and effective treatment strategies in the field of biomedical engineering.

Keywords: localized hyperthermia, drug delivery, implantable biomedical device, theoretical modeling, computational modeling, finite element analysis, computational fluid dynamics.

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