THE EFFECT OF RANITIDINE ON THE ABSORPTION KINETICS OF METRONIDAZOLE

THE EFFECT OF RANITIDINE ON THE ABSORPTION KINETICS OF METRONIDAZOLE

Abstract:

The effect of a singleoral dose of ranitidine I50mg was s t u d i e d on t h e a b s o r p t i o n and pharmacokinetic parameters of metronidazole following a s i n g l e o r al dose of 4OOmg in four h e a l t h y v o l u n t e e r s (age 28-35, weight 50-65kg) administered one hour a f t e r r a n i t i d i ne i n a c r o s s – o v e r s t u d y. The a d m i n i s t r a t i o n of r a n i t i d i n e l50mg an hour b e f o r e the dose of metronidazole did not a f f e ct s i g n i f i c a n t l y the mean a b s o r p t i o n and pharmacokinetic parameters of metronidazole ( p > 0 . 5 ) . Ranitidine i n c r e a s e d Kabs by 20.5%, t1 / 2 by 10.15%, Tiag by 60.8% and d e c r e a s e d Tmax and Cmax by 7% and 3,kh% r e s p e c t i v e ly ( i n a l l cases P > 0 . 0 5 ) . S i m i l a r l y , Kel and ClTBC were d e c r e a s e d by 8.11% and 1.1% (P> 0 . 1 and > 0.5 r e s p e c t i v e l y ) while t1/2, Vd and AUC were i n c r e a s e d by 8.26%, 6.8% and 1.92% r e s p e c t i v e l y ( P > 0 . 1 , > 0.5 and > 0 . 5 ) . S i m i l a r t o r e s u l t s obtained i n previous s t u d i e s, t h e r e were v a r i a t i o n s in t h e plasma c o n c e n t r a t i o n s and p h a r m a c o k i n e t i c parameters of metronidazole in man. The e f f e c t of r a n i t i d i n e on t h e k i n e t i c s of metronidazole was h i g h l y v a r i a b l e and in some v o l u n t e e r s it was s u b s t a n t i a l . It i s concluded t h a t d e s p i t e the l a r ge i n t e r – i n d i v i d u a l d i f f e r e n c e s , r a n i t i d i n e does not a l t er the mean pharmacokinetics of metronidazole in man, but that simply using the mean data for comparison could be misleading

THE EFFECT OF RANITIDINE ON THE ABSORPTION KINETICS OF METRONIDAZOLE

Sharing is caring!