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SERUM LEVELS OF PLACENTA GROWTH FACTORS (PLGF) AND SOLUBLE FMS-LIKE TYROSINE KINASE 1(sFLT-1) IN PRE-ECLAMPSIA (CASE-CONTROL STUDY) AT THE LAGOS STATE UNIVERSITY TEACHING HOSPITAL, IKEJA
Abstract
BACKGROUND: The aim was to compare the serum levels and ratio of angiogenic factor- placenta growth factor (PLGF) and anti angiogenic factor -soluble fms-like tyrosine kinase 1 (sFlt1) in women with pre-eclampsia and normotensive pregnant women in Lagos State University Teaching Hospital.
METHODS: Structured proformer was used to collect data on socio-demography, clinical characteristics and fetomaternal outcome of pregnant pre eclamptic and normotensive women
in their third trimester. Samples were collected for assay of PLGF and sFlt-1 and analysis was done using the immunoassay technique .Data analysis was done by Epi info 3.5.3 and SPSS version 20.0. Data was expressed as Mean ± Standard Deviation. Comparison of serum levels of the analytes between the two groups was done using the Independent t-test and Chi-square test. Correlation was done using the Pearson’s coefficient and the risk of adverse fetomaternaloutcome was determined using the logistics regression. P-value of < 0.05 was considered as statistically significant.
RESULTS: The mean sFlt-1 and sFlt1/PLGF ratio (in pg/ml) for the patients in the pre- eclampsia group were 6581.86 ± 865.75, and 146.42 ±92.43 were significantly higher than in normotensive control group 4584.52 ± 1479.6 and 11.60 ± 6.42 respectively,(p< 0.05).At the
same time, PLGF was significantly lower in pre eclamptic patients (70.14± 51.03) compared to the normotensives 494.06 ± 475.8 (p<0.05).There was a positive and negative correlation between the sFlt-1 and PLGF respectively and mean arterial blood pressure.
CONCLUSION: Pre-eclamptic subjects had higher serum levels of sFlt-1, sFlt1/PLGF ratio and decreased PLGF levels compared to Normotensive subjects. The values of these analytes correlated with severity of pre-eclampsia.
