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PREVALENCE OF ANAEMIA OF CHRONIC DISEASE, AND ESTIMATION OF SERUM ERYTHROPOIETIN LEVELS IN PATIENTS WITH CHRONIC DISEASE IN JOS UNIVERSITY TEACHING HOSPITAL (JUTH)
Abstract
Objective: The objective was to document the laboratory characteristics
of Anaemia of Chronic Disorders including determination of
serum EPO Levels in these patients.
Design: What is cross – Sectional descriptive study
Subject: 215 patients consisting of 90 as controls (patients that did not
have chronic disease) and 125 patients that had chronic
diseases who presented in the outpatient department clinics
of the Jos University Teaching Hospital were recruited.
Method:
Subject biodata and focused clinical history were recorded, full blood count, serum
iron, serum ferritin and serum EPO were performed) on all subjects as described
by standard methods and according to kits manufacture’s instructions.
Result: of the 125 with chronic disorders only 90 72% had anaemia
(PVC<33%).of the 90 that had anaemia 82 (82/125 = 65.5%) had laboratory
features of ACD (low sermon iron and high ferritin levels). The serum iron and
ferritin levels of the controls (18.98+165 respectively) were significantly different
from that of the 82 subject with ACD (6.8+242 respectively) )P+0.00,P+ 0.00
respectively).
Appropriateness of EPO response to anaemia was determined by establishing an
exponential relationship between EPO levels of controls and Hb levels of control.
Log EPO +22.446-0.11 x Hb g / dl was establish EPO levels of anaemic subjects
by putting their Hb concentrations into the equation. The resulting EPO values
were regarded as predicted values. A ratio of observed value over predicted values
(O/P ratio) were calculated. O/P ratio <0.8 was accepted as inappropriate response.
Patients with ACD had significantly higher (32.1+10.1), P+0.00. Thirty (33%) of
the 90 anaemic patients had OPratio less than 0.8 (<0.8). 4 p2 The serum ferritin
levels of those
