SERUM LEVELS OF TROPONIN I, MYOGLOBIN AND CREATINE KINASE-MB IN THE OBESE

Abstract

AIMS AND OBJECTIVES
Obesity is becoming a global epidemic in both children and adults. The
dramatic increase in the prevalence of obesity and its strong
association with cardiovascular disease has resulted in unprecedented
interest in understanding the effect of obesity on the cardiovascular
system. The European society of cardiologists (ESC) and American
College of Cardiology (ACC) consensus conference have codified the
role of cardiac markers by advocating that the diagnosis of myocardial
infarction be evidence of myocardial injury based on markers if heart
is damaged in the appropriate clinical situation.
The aim of this study is to determine and compare the serum levels of
troponin I, creatine kinase MB and myoglobin in obese subjects and
healthy controls.

PATIENTS AND METHODS:
Two hundred obese subjects aged between 20 and 40 years were
studied along with two hundred age and gender-matched apparently
healthy controls. The height and weight of the participants were
measured and the body mass index calculated.
The serum troponin I, myoglobin and creatine kinase-MB were
estimated.
13

RESULTS:
The mean age of the obese subjects was 34.74 ± 4.33 years and it was
not significantly different from that of the controls which was 34.14 ±
3.45 years.
The body mass index was significantly higher in the obese subjects.
The troponin I and creatine kinase-MB concentration were
significantly lower in the obese compared to the non obese. On the
other hand there was no statistical significant difference in the mean
serum concentration of the myoglobin of the obese compared to the
non obese

CONCLUSION:
The serum levels of CK-MB and troponin I are lower in obese subjects
in UPTH.

SERUM LEVELS OF TROPONIN I, MYOGLOBIN AND CREATINE KINASE-MB IN THE OBESE