HISTOPATHOLOGICAL PATTERN OF PROSTATIC DISEASES AT THE UNIVERSITY OF BENIN TEACHING HOSPITAL: A PROSPECTIVE AUTOPSY STUDY, MAY 2013 – JULY 2014.

Abstract

Background: Most autopsy studies on prostate gland are limited to malignant prostatic tumours.
The possibilities of finding other histological types of prostatic diseases was worth exploring
bearing in mind that Nodular hyperplasia and cancer are of epidemiological importance.
Aims and Objectives: The aim of this study is to determine the pattern of prostatic diseases at
autopsy among individuals not previously diagnosed with prostate disease and who died from
other causes.
Materials and Methods: Prostate glands at autopsy were obtained from individuals who died
from non-prostate related causes, weighed, fixed in 10% neutral buffered formalin, processed
and histologically analysed. Biodata and clinical diagnoses were obtained using clinical case
notes and autopsy register.
Results: The population under study were 86 adult males whose ages ranged from 30 to 85 years
with a mean age of 52.71 ± 13.10 years. Ninety three percent (93% / 80 cases) of the study
population were afflicted with prostatic diseases at autopsy. The most common lesion was
nodular hyperplasia (77.9% / 67 cases). This was followed by latent or occult adenocarcinoma
(8.1% / 7 cases), High grade prostatic intraepithelial neoplasia [HGPIN] (5.8% / 5 cases) and
Schistosomiasis (1.2% / one case) in decreasing order of frequency. The frequency of occult
adenocarcinoma, high grade prostatic intraepithelial neoplasia (HGPIN) and nodular hyperplasia
increased significantly with age (p ≤ 0.05). The peak age for the diagnosis of occult
adenocarcinoma, HGPIN and nodular hyperplasia were in the 6th, 8th and 6th decades of life
respectively.

Conclusions:
Clinically concealed prostatic diseases are common findings at autopsies. There is a significant
increase (p ≤ 0.05) in the frequency of covert prostatic diseases (nodular hyperplasia, HGPIN
and adenocarcinoma) with age. Future autopsy study may find whole prostate gland analysis and
immunohistochemical studies invaluable.

HISTOPATHOLOGICAL PATTERN OF PROSTATIC DISEASES AT THE UNIVERSITY OF BENIN TEACHING HOSPITAL: A PROSPECTIVE AUTOPSY STUDY, MAY 2013 – JULY 2014.