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PH- RESPONSIVE DEXTRAN GATED FUNCTIONIZED MESOPOROUS SILICA FOR DRUG DELIVERY
Abstract:
In recent years, the development of innovative drug delivery systems has gained significant attention in the field of pharmaceutical research. One promising approach involves the utilization of mesoporous silica nanoparticles (MSNs) as carriers for therapeutic agents due to their unique physicochemical properties. To enhance the controlled release of drugs, regulating the release kinetics in response to specific environmental cues, such as pH, has become a focal point of research. This abstract presents a novel drug delivery system based on pH-responsive dextran-gated functionalized mesoporous silica nanoparticles.
The proposed drug delivery system consists of mesoporous silica nanoparticles with a high surface area and pore volume, allowing for efficient drug loading. The surface of the nanoparticles is functionalized with pH-responsive dextran polymer chains, which serve as gatekeepers for the drug release. Under specific pH conditions, the dextran chains undergo conformational changes, leading to the opening of the nanoparticle pores and subsequent drug release.
The pH responsiveness of the dextran-gated mesoporous silica system offers several advantages. Firstly, it enables selective drug release at the target site, such as tumor tissues or specific compartments within cells, where the pH environment is known to be altered compared to healthy tissues. Secondly, it allows for enhanced drug stability during circulation, as the dextran gates prevent premature drug release in the bloodstream. Moreover, the system can be tailored to respond to different pH ranges, providing versatility for various therapeutic applications.
The fabrication of the pH-responsive dextran-gated mesoporous silica nanoparticles involves a combination of synthetic chemistry techniques, including mesoporous silica synthesis, surface functionalization, and polymer conjugation. The physicochemical properties of the nanoparticles, such as particle size, pore size, and surface charge, can be optimized to achieve desired drug loading and release profiles.
In conclusion, the pH-responsive dextran-gated functionalized mesoporous silica system holds great potential as an advanced drug delivery platform. Its ability to respond to pH stimuli offers precise control over drug release, improving therapeutic efficacy and minimizing off-target effects. Further research and development in this area may lead to the translation of this system into clinical applications, benefiting patients by providing targeted and personalized drug delivery strategies.
Keywords: drug delivery, mesoporous silica nanoparticles, pH-responsive, dextran-gated, controlled release, nanomedicine.
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